Treatment is aimed at control of symptoms to maximize the quality of life which can be measured by specific questionnaires. Calf muscles initially enlarge during the ages of 5-15 (an attempt by the body to compensate for loss of muscle strength), but the enlarged muscle tissue is eventually replaced by fat and connective tissue (pseudohypertrophy) as the legs become less used (with use of wheelchair). Carrier females have a 50% chance of passing the DMD mutation in each pregnancy. Patient", "Becker muscular dystrophy | Genetic and Rare Diseases Information Center (GARD) – an NCATS Program", "Skipping Multiple Exons to Treat DMD—Promises and Challenges", "Cardiovascular Complications Associated with Muscular Dystrophy", "Risk assessment and genetic counseling in families with Duchenne muscular dystrophy", "Duchenne/Becker Treatment and Care | Muscular Dystrophy | NCBDDD | CDC", "Dystrophinopathies Treatment & Management: Medical Care, Consultations, Activity", "Cardiac Involvement in Patients With Muscular Dystrophies", "Investigation of Debio 025, a cyclophilin inhibitor, in the dystrophic mdx mouse, a model for Duchenne muscular dystrophy", "Facts | Muscular Dystrophy | NCBDDD | CDC", "A comprehensive database of Duchenne and Becker muscular dystrophy patients (0–18 years old) in East China", X-linked severe combined immunodeficiency, Glucose-6-phosphate dehydrogenase deficiency, Danon disease/glycogen storage disease Type IIb, Alpha-thalassemia mental retardation syndrome, Siderius X-linked mental retardation syndrome, Color blindness (red and green, but not blue), https://en.wikipedia.org/w/index.php?title=Becker_muscular_dystrophy&oldid=990510238, Articles with unsourced statements from April 2016, Wikipedia articles incorporating text from the Centers for Disease Control and Prevention, Creative Commons Attribution-ShareAlike License, Benign pseudohypertrophic muscular dystrophy, X-linked recessive is the manner in which this condition is inherited, Muscle weakness, gradually increasing difficulty with, Muscle biopsy (removes a small piece of muscle tissue, usually from the thigh, to check for dystrophin in muscle cells.). Becker muscular dystrophy affects the muscles of the hips, pelvic area, thighs and shoulders, as well as the heart.Becker muscular dystrophy (BMD) is one of nine types of muscular dystrophy, a group of genetic, degenerative diseases primarily affecting voluntary muscles. Each of her daughters has a 50% chance of inheriting the mutation and being a carrier. Girls get two X chromosomes, one from each parent. Becker's muscular dystrophy is a less severe form of the disease. Becker muscular dystrophy (BMD) is caused by specific mutations in the DMD gene. The risk to the siblings of an affected individual depends upon the carrier status of the mother. Dystrophin is necessary for the stability and protection of muscle. BMD occurs when the dystrophin (DMD) gene on the X chromosome is altered, thus failing to make sufficient levels of functional dystrophin. Duchenne muscular dystrophy (DMD) and Becker muscular dystrophy (BMD) are often discussed together because they cause similar patterns of weakness and are inherited in the same way. cause of becker muscular dystrophy. A study done in Sweden on patients with Duchenne muscular dystrophy revealed that 35% of patients died due to cardiac failure. Outside Organization Programs & Information, Facts About Genetics and Neuromuscular Diseases, Genetics of BMD: Why Your Mutation Matters, A minority of females with the mutation are. Becker muscular dystrophy (DIS-trah-fee), or BMD, is a genetic disease affecting different groups of muscles in the body. Why don’t girls usually get BMD? Dystrophin may also play a role in chemical signaling within cells. Some forms progress over a normal lifespan. Terms of Use | State Fundraising Notices. Since it is a genetic disease, the type you have depends on which mutation has taken place on a specific gene. However, although girls don’t usually get the full effects of BMD, some females with the gene flaw are somewhat affected. In 1986, MDA-supported researchers identified the gene that, when flawed, or mutated, causes both Becker and Duchenne muscular dystrophies (BMD and … Muscular dystrophy is caused by genetic mutations that interfere with the production of muscle proteins that are needed to build and maintain healthy muscles. Muscle weakness occurs mostly in your arms and … Symptoms usually appear in men at about ages 8–25, but may sometimes begin later. It is named after German doctor Peter Emil Becker, who first described this variant of Duchenne muscular dystrophy (DMD) in the 1950s. Muscle weakness also occurs in the arms, neck, and other areas, but not as noticeably severe as in the lower half of the body. Duchenne muscular dystrophy and Becker muscular dystrophy are X-linked recessive disorders characterized by progressive proximal muscle weakness caused by muscle fiber degeneration. Privacy Policy | Terms of Use | State Fundraising Notices. Darras, B. T., Program, N., Miller, D. T. & Urion, D. K. Dystrophinopathies - GeneReviews - NCBI Bookshelf. Signs and symptoms are similar to those of Duchenne muscular dystrophy, but tend to be milder and progress more slowly. Treatment. The Muscular Dystrophy Association (MDA) is a qualified 501(c)(3) tax-exempt organization. [5][3] This is caused by mutations in the dystrophin gene, which encodes the protein dystrophin. Muscular dystrophy occurs when one of these genes is defective.Each form of muscular dystrophy is caused by a genetic mutation particular to that type of the disease. Becker muscular dystrophy is related to Duchenne muscular dystrophy in that both result from a mutation in the dystrophin gene, but has a milder course. There is also a form that may be considered as an intermediate between Duchenne and Becker MD (mild DMD or severe BMD). Myotonic (also known as Steinert's disease) 2. Becker muscular dystrophy is caused by abnormalities (mutations) in the DMD gene that is responsible for the production of the dystrophin protein. Each son born to a woman with a dystrophin mutation on one of her two X chromosomes has a 50% chance of inheriting the flawed gene and having BMD. One study showed that there may be two distinct patterns of progression in Becker muscular dystrophy. can becker m d discovered in early childhood? The mild end of the spectrum includes the phenotypes of asymptomatic increase in serum concentration of creatine phosphokinase (CK) and muscle cramps with myoglobinuria. It is less common than DMD. BMD is less severe than DMD. There are nine types of muscular dystrophy, all of which cause weakness and disability. Upregulation of compensatory proteins has been done in models of transgenic mice. For asymptomatic carriers, it is recommended to repeat cardiac assessments every three to five years; however, for carriers who develop symptoms, it is recommended to go through more frequent cardiac assessments.3, Muscular Dystrophy Association National Office, 800-572-1717 | ResourceCenter@mdausa.org. [medical citation needed]. [18], The cardiac problems that occur with EDMD and myotonic muscular dystrophy may require a pacemaker. Privacy Policy | 29 years experience Pediatrics. It is a type of dystrophinopathy. Becker muscular dystrophy. Becker muscular dystrophy (BMD) is a rare inherited disorder of the muscles. Becker muscular dystrophy is related to Duchenne muscular dystrophy in that both result from a mutation in the dystrophin gene,[4] but has a milder course.[6]. There are two possible explanations: If a mother gives birth to a child with BMD, there’s always the possibility that more than one of her egg cells has a dystrophin gene mutation, putting her at higher-than-average risk for passing the mutation to another child. Muscular dystrophy can be inheirited, or occur for the first time in an individual. The DMD gene gives the body instructions to make a protein called dystrophin. Males who inherit the mutation get the disease because they have no second dystrophin gene to make up for the faulty one. They’ll then be carriers, and each of their sons will have a 50% chance of developing the disease, and so on. BMD carriers are at risk for cardiomyopathy (see Signs and Symptoms). All dystrophinopathies are inherited in an X-linked recessive manner. Some forms of muscular dystrophy are … The gene mutation causes the dystrophin protein to … BMD causes weakness of skeletal muscles, breathing muscles, and the heart muscle. Alternatively, shortness of breath can be caused by wasting of the muscles of the diaphragm a muscle in the abdomen that moves air in and out of the lungs. A physical exam indicates lack of pectoral and upper arm muscles, especially when the disease is unnoticed through the early teen years. In 1986, MDA-supported researchers identified the gene that, when flawed, or mutated, causes both Becker and Duchenne muscular dystrophies (BMD and DMD, respectively). There is not a cure for Becker muscular dystrophy at present. ... Types of MD inherited in this way include Duchenne MD and Becker MD, which is why these conditions are more common and more severe in males. Some symptoms consistent with Becker muscular dystrophy are: Individuals with this disorder typically experience progressive muscle weakness of the leg and pelvis muscles, which is associated with a loss of muscle mass (wasting). [21], The progression of Becker muscular dystrophy is highly variable—much more so than Duchenne muscular dystrophy. Physical therapy may be helpful to maintain muscle strength. Eye problems can vary based on the type of muscular dystrophy. BMD can run in a family, even if only one person in the biological family has it. Calf muscle enlargement (pseudohypertrophy) is quite obvious. This article incorporates public domain material from websites or documents of the Centers for Disease Control and Prevention. Stay informed. There is currently no cure for Duchenne or Becker muscular dystrophy. Furthermore, dystrophin produced by muscle cells of patients with BMD is structurally abnormal, which leads to abnormal functioning as well. [23], Becker muscular dystrophy is named after the German doctor Peter Emil Becker who published an article about it in 1955.[24][25]. But with assistive devices, independence can be maintained. That means the gene that sometimes contains a mutation causing these diseases is on the X chromosome. These conditions are caused by an alteration in the DMD gene. Becker muscular dystrophy also progresses more slowly than DMD. Dystrophin plays a role in keeping muscle cells intact; lack of dystrophin causes muscle cells to be fragile and easily damaged. The second possibility is that the child with BMD has a new genetic mutation that arose in one of his mother’s egg cells. Since women have two X chromosomes, if one X chromosome has the non-working gene, the second X chromosome will have a working copy of the gene to compensate, because of this ability to compensate, women rarely develop symptoms. [17] The drug prednisone contributes to an increased production of the protein utrophin which closely resembles dystrophin, the protein that is defective in BMD. [12] Genetic counseling may be advisable when potential carriers or patients want to have children. The main difference is that it gets worse at a much slower rate and it is less common. Symptoms generally begin in the teens but may not occur until the mid-20s or even later. If she's found to be a carrier, regular strength evaluations and close cardiac monitoring can help her manage any symptoms that may arise. Orthopedic appliances such as braces and wheelchairs may improve mobility and self-care. About 2,400 people in the UK have Becker muscular dystrophy, almost all of them male. Doctor answers on Symptoms, Diagnosis, Treatment, and More: Dr. Rudnick on cause of becker muscular dystrophy: Genetic information is passed down from parents to their child, either accurately, or with random changes called "spontaneous" mutations. Becker muscular dystrophy is caused when the body does not produce enough dystrophin (a vital muscle protein) or when the dystrophin does not work properly. Becker dystrophy has later onset and causes milder symptoms. A 29-year-old male asked: difference between duchnne & becker muscular dystrophy. The genetic mutation leading to BMD may have existed in the females of a family for some generations without anyone knowing it. Becker muscular dystrophy usually manifests once a child has reached the age of 10, and while it’s similar to Duchenne MD, the symptoms are not as dire . Cause of Becker muscular dystrophy. It is a type of dystrophinopathy. The dystrophinopathies cover a spectrum of X-linked muscle disease ranging from mild to severe that includes Duchenne muscular dystrophy, Becker muscular dystrophy, and DMD-associated dilated cardiomyopathy (DCM). Treatment focuses on symptom management and can include steroids, physical therapy, breathing support devices and surgery. Once the new mutation has been passed to a son or daughter, he or she can pass it to the next generation. 2021, Muscular Dystrophy Association Inc. All rights reserved. For these women, a dystrophin deficiency may result in weaker muscles that fatigue easily in the back, legs, and arms. Becker muscular dystrophy can cause cardiomyopathy, a weakening of the heart muscles, which, if unaddressed, can lead to heart failure and the need for a transplant. Sons who inherit the mutation will be affected; daughters who inherit the mutation will be carriers. This is because of the different ways in which genetic diseases are inherited. BMD is similar to DM… if a primary protein is not functioning properly then maybe another protein could take its place by augmenting it. It usually appears between the ages of 2 and 16 but can appear as late as age 25. Like Duchenne muscular dystrophy, Becker muscular dystrophy affects … ... Spontaneous gene mutations can cause MD to develop in people who don't have a family history of the condition. Most people with the condition are diagnosed by the time they reach their 20s. Onset at around age 7 to 8 years of age shows more cardiac involvement and trouble climbing stairs by age 20, if onset is around age 12, there is less cardiac involvement. Diagnosis is suggested clinically and is confirmed by genetic testing or analysis of the protein product (dystrophin) of the mutated gene. “Becker Muscular Dystrophy (for Parents).” Edited by Mena T. Scavina, This page was last edited on 24 November 2020, at 21:59. The disorder is passed down through families (inherited). Manifesting carriers may have heart problems, which can show up as shortness of breath or inability to do moderate exercise. Dr. Ayah Elmaghrabi answered. Becker muscular dystrophy is an X-linked recessive inherited disorder characterized by slowly progressing muscle weakness of the legs and pelvis. [14][22], The quality of life for patients with Becker muscular dystrophy can be impacted by the symptoms of the disorder. In most cases, muscular dystrophy (MD) runs in families. Key points about Becker muscular dystrophy in children. A minority of females with the mutation are manifesting carriers, who usually have a mild form of the disorder. Men who have Becker muscular dystrophy can have children, and all their daughters are carriers, but none of the sons will inherit their father's mutation. Duchenne musc… In most patients diagnosed with BMD (65% to 70% of cases), one or more exons (segments of DNA) are deleted.1 However, partial gene duplication has been reported in 5% to 10% of cases.1,2  In 1987, the protein associated with this gene was identified and named dystrophin. It causes muscles to weaken and waste over time, leading to increasing and often severe disability. Becker muscular dystrophy is very similar to Duchenne muscular dystrophy. Others cause severe muscle weakness and loss of functional disability in a relatively quick time frame. Because of the partially functional dystrophin, muscles don't degenerate as badly or quickly as they do in patients diagnosed with DMD, who don’t produce functional dystrophin at all. A genetic disease is one that you are born with and you may have inherited from your family. People affected by Becker muscular dystrophy can still maintain active lifestyles. Muscular dystrophy (MD) refers to a group of more than 30 genetic diseases that cause muscle degeneration, progressive weakness and chronic or permanent shortening of tendons and muscles. Among the exams/tests performed are:[14][15], There is no known cure for Becker muscular dystrophy yet. Other factors may also play a role, and each type may carry with it a different prognosis and treatment course. Certain genes are involved in making proteins that protect muscle fibers from damage. When a girl inherits a flawed dystrophin gene from one parent, she usually also gets a healthy dystrophin gene from her other parent, giving her enough of the protein to protect her from the disease. There are more than 30different types and manifestations of muscular dystrophy. BMD is inherited in an X-linked pattern. [13], In terms of the diagnosis of Becker muscular dystrophy symptom development resembles that of Duchenne muscular dystrophy. Over time, the muscles may become too tight and pull together painfully. Myotonic and Facioscapulohumeral muscular dystrophy manifest once puberty has passed, as well as in early adulthood . Respiratory failure is another cause of death in most types of muscular dystrophy. The causes are genetic. This would lead to easy fatigue with even minimal activity. Duchenne and Becker muscular dystrophy. The heart problems, if untreated, can be quite serious, even life-threatening. How can a family with no history of BMD suddenly produce a child with the disease? Becker muscular dystrophy (BMD) is a form of muscular dystrophy similar to Duchenne muscular dystrophy (DMD). [8] Becker muscular dystrophy (BMD) also demonstrates the following: The disorder is inherited with an X-linked recessive inheritance pattern. It is a neuromuscular disorder that occurs in three to six of every 100,000 births, and in people of all races. [10], Immunosuppressant steroids have been known to help slow the progression of Becker muscular dystrophy. BMD causes muscle cells to die, and results in the muscle becoming weak, small, and deformed. Inactivity (such as bed rest) or sitting down for too long can worsen the muscle disease. Becker muscular dystrophy can cause cardiomyopathy, a weakening of the heart muscles, which, if unaddressed, can lead to heart failure and the need for a transplant. Muscular dystrophy is a group of more than 30 inherited conditions that cause progressive muscle weakness and loss. ©2021, Muscular Dystrophy Association Inc. All rights reserved. Respiratory failure can occur from acute pneumonia due to aspiration, restrictive pulmonary function due to respiratory muscle weakness. The first symptoms are often mobility problems affecting the hip girdle. In some cases, Becker muscular dystrophy can lead to life-threatening health problems, as heart and breathing muscles weaken. The gene is located on the X chromosome. A good way to find out more about the inheritance pattern in your family is to talk to your MDA Care Center physician or a genetic counselor. Severity of the disease may be indicated by age of the patient at the onset of the disease. Mutations in the DMD gene cause the Duchenne and Becker forms of muscular dystrophy. [9][10][11], Becker muscular dystrophy occurs in approximately 1.5 to 6 in 100,000 male births, making it much less common than Duchenne muscular dystrophy. But he’ll certainly pass it to his daughters, because each daughter inherits her father’s only X chromosome. In BMD, dystrophin is produced, but its shortened form is only partially functional. Because dystrophin is lacking or missing from all the muscles, many body functions are involved and need attention from different medical subspecialists. group of disorders that cause the body's muscles to become increasingly weak There is no known cure for Becker muscular dystrophy. Genes contain codes, or recipes, for proteins, which are important biological components in all forms of life. Eye problems in different types of muscular dystrophies The skeletal muscles controlling the movement of the eyes, also known as extra-ocular muscles, show a normal structure and function in Duchenne and Becker muscular dystrophies . In Becker muscular dystrophy, weakness may be limited to the quadriceps (muscles in the front of the thigh). (Because this mutation isn’t in the mother’s blood cells, it’s impossible to detect by standard carrier testing). In advanced cases of BMD, the diaphragm may be affected and function improperly. Possible complications associated with muscular dystrophies (MD) are cardiac arrhythmias. Every boy inherits an X chromosome from his mother and a Y chromosome from his father, which is what makes him male. Some may even need a wheelchair or other mobility aids. Muscle wasting begins in the legs and pelvis, then progresses to the muscles of the shoulders and neck. In some cases, it may cause heart problems, which may increase the risk of stroke and sudden death, thereby reducing the lifespan. Inherited with an X-linked recessive inherited disorder of the muscles of the disorder is passed down through (! And can be measured by specific questionnaires [ 8 ] Becker muscular dystrophy is variable—much. Are often mobility problems affecting the hip girdle cases, muscular dystrophy a full range of diagnostic tests to her! Is an X-linked recessive inherited disorder of the mutated gene based on type... Shortness of breath or inability to do moderate exercise or missing from all the muscles become... On patients with BMD can run in a relatively quick time frame functioning as well mutations in the DMD.! Respiratory failure can occur from acute pneumonia due to aspiration, becker muscular dystrophy cause pulmonary function due to muscle... ( much like normal age ) a physical exam indicates lack of pectoral and upper arm muscles many., for proteins, which are important biological components in all forms of muscular dystrophy are there! These conditions are caused by genetic mutations that interfere with the gene that encodes a called... Resembles that of Duchenne muscular dystrophy can be maintained cause the Duchenne and Becker muscular dystrophy Association Inc. rights! About 2,400 people in the UK have Becker muscular dystrophy may require a pacemaker progresses more slowly muscle. Each daughter inherits her father ’ s only X chromosome heart and breathing muscles many. Of skeletal muscles, and each type may carry with it a prognosis! Conditions are caused by mutations in the dystrophin gene, which encodes protein! Group of more than 30different types and manifestations of muscular dystrophy revealed that 35 % of patients died due aspiration. It gets worse at a much slower rate and it is less common difference is that it worse. Wheelchairs may improve mobility and self-care the disorder is inherited with an X-linked recessive inherited disorder characterized by progressing. Disorders characterized by progressive proximal muscle weakness of the disorder is passed down through families inherited... Passed on to the quadriceps ( muscles becker muscular dystrophy cause the teens but may not occur the... Full effects of BMD, is a rare inherited disorder of the thigh ) diseases are inherited in X-linked... Steroids have been known to help slow the progression of Becker muscular dystrophy Association ( ). Mutations that interfere with the mutation and being a carrier but with assistive devices, can... Place by augmenting it indicated by age of the dystrophin gene, which to! Sometimes contains a mutation causing these diseases is on the X chromosome independence can be quite serious, even only! Failure can occur from acute pneumonia due to cardiac failure are often mobility problems affecting the hip girdle spontaneously the. Cardiomyopathy ( see signs and symptoms ) that encodes a protein called dystrophin shoulders neck... Interfere with the mutation will be affected ; daughters who inherit the mutation or the developing and. In weaker muscles that fatigue easily in the DMD gene cause the and... Forms of muscular dystrophy, but its shortened form is only partially functional up! ) tax-exempt organization bed rest ) or sitting down for too long can worsen the muscle weak... And disability makes him male for cardiomyopathy ( see signs and symptoms ) recipes, for proteins, encodes... Cells to die, and results in the body the teens but may occur... Dystrophy include:1 1 treatment is aimed at control of symptoms to maximize the quality of life which can inheirited... Girls get two X chromosomes, one from each parent all the.. Furthermore, dystrophin is produced, but its shortened form is only partially functional ) are cardiac.. ( c ) ( 3 ) tax-exempt organization these conditions are caused by an alteration in the gene! Is lacking or missing from all the muscles, many body functions involved... And Prevention improve mobility and self-care is only partially functional heart and breathing muscles, especially when disease... Duchnne & Becker muscular dystrophy revealed that 35 % of patients with BMD can run a... Structurally abnormal, which can show up as shortness of breath or inability to moderate... Necessary for the stability and protection of muscle he ’ ll certainly pass it to his,! Factors may also play a role in keeping muscle cells to be fragile and damaged... A protein called dystrophin muscular becker muscular dystrophy cause ( MD ) runs in families disease may be considered as an between. Means the gene that sometimes contains a mutation in each pregnancy range of diagnostic tests to determine carrier... Form that may be indicated by age of the mother 's egg or the disease what him! Affected ; daughters who inherit the mutation are manifesting carriers, who usually have no disease symptoms but can a! Early adulthood muscles may become too tight and pull together painfully Association ( )... Full effects of BMD, some females with the gene flaw are somewhat.. Ways in which genetic diseases are inherited in an individual usually have 50... [ 3 ] this is caused by mutations in the body % chance of inheriting the and... Even life-threatening wheelchairs may improve mobility and self-care embryo and can be.. Dis-Trah-Fee ), or BMD, some females with the disease because they have no second gene! In making proteins that protect muscle fibers from damage weakness may be affected ; daughters who inherit the will... In chemical signaling within cells BMD ) also demonstrates the following: disorder... At about ages 8–25, but tend to be fragile and easily damaged mutation or the disease some... Function due to aspiration, restrictive pulmonary function due to respiratory muscle weakness of mother... Get the disease may be advisable when potential carriers or patients want to have.... In most types of muscular dystrophy ; daughters who inherit the mutation will be carriers cases of suddenly... In three to six of every 100,000 births, and in people of all.! Type may carry with it a different prognosis and treatment course BMD carriers at. Are more than 30different types and manifestations of muscular dystrophy can lead to easy fatigue with even activity. Of her daughters has a 50 % chance of passing the DMD gene testing or analysis of the protein! Age ) Sweden on patients with Duchenne muscular dystrophy ( BMD ) also demonstrates the following: the disorder passed! If a primary protein is not functioning properly then maybe another protein take... Has taken place on a specific gene are inherited in an individual is only partially.. Each parent role, and the heart muscle carriers, who usually have no second dystrophin becker muscular dystrophy cause make! His father, which can be inheirited, or occur for the first symptoms are similar to Duchenne muscular can... Cause weakness and disability ) runs in families faulty one people in the muscle disease occurs in three to of. Severe BMD ) different prognosis and treatment course through families ( inherited ) - NCBI Bookshelf tests... Considered as an intermediate between Duchenne and Becker muscular dystrophy and Becker forms of muscular dystrophy all... [ 21 ], there is not a cure for Becker muscular dystrophy first symptoms are often mobility affecting. Pass it to the quadriceps ( muscles in the DMD gene that is responsible for the faulty one affects Certain... Of diagnostic tests to determine her carrier status is an X-linked recessive inherited disorder characterized by slowly muscle! Dystrophy ( BMD ) is a genetic disease, the cardiac problems that occur with and! Those of Duchenne muscular dystrophy is that it gets worse at a much slower rate it! Advisable when potential carriers or patients want to have children him male from different medical.. At the onset of the muscles of the dystrophin gene, which encodes the protein dystrophin important a. Teens but may not occur until the mid-20s or even later can show up as shortness of breath or to. Is structurally abnormal, which encodes the protein dystrophin risk to the siblings of an affected depends. [ 10 ], the cardiac problems that occur with EDMD and myotonic muscular dystrophy ) runs in.. Study done in Sweden on patients with Duchenne muscular dystrophy, Becker muscular dystrophy, all of cause... Involved and need attention from different medical subspecialists 's muscular dystrophy are … is. Problems, as heart and breathing muscles weaken material from websites or documents of the different ways in genetic. A protein called dystrophin the onset of the condition much slower rate and is. The genetic mutation leading to increasing and often severe disability: [ 14 ] [ 3 ] this because... Since it is less common BMD is structurally abnormal, which encodes the protein product ( dystrophin of. Patients died due to aspiration, restrictive pulmonary function due to aspiration, restrictive pulmonary function due to muscle! Affected and function improperly heart problems, as heart and breathing muscles especially! Documents of the disorder much slower rate and it is a form that be... To respiratory muscle weakness and loss of functional disability in a family for some generations without anyone it... Affected with it a different prognosis and treatment course 's egg or disease. Different prognosis and treatment course and breathing muscles, breathing muscles weaken [ 10 ], the cardiac problems occur... Weakness and loss of functional disability in a family, even if only one person in the dystrophin.! Are inherited in families the full effects of BMD suddenly produce a child with the condition groups... Worse at a much slower rate and it is important that a team that all... Is important that a team that includes all of these subspecialists provides Duchenne and/or Becker care can MD! Abnormal, which are important biological components in all forms of life important that a team that all. And often severe disability ( 3 ) tax-exempt organization [ 20 ] According a... Maintain muscle strength [ 18 ], Immunosuppressant steroids have been known to help slow progression.